Research Projects

Cell and developmental biology of Marine organisms

Funding Agency: Department of Biotechnology, Govt of India

Project Type: Multi Institutional

Period of Study: 02/09/2021 to 01/09/2024

Project Coordinator: Prof.I. S. Bright Singh

PI: Prof. Valsamma Joseph and Dr. Jayesh Puthumana

Co-I: Mr. Shibin S. P.

Project Cost: Rs. 301.23 lakhs

Collaborating Institutions: 1. C Abdul Hakeem College, Vellore
                                                              2. Bharathidasan University, Thiruchirapalli

Establishment of Functional Genomics and Metabolomics Platform for Augmented Production of Aquatic Bio-Resources and Discovery of Novel Molecules of Biomedical Importance.

Funding Agency: Higher Education Department, Govt. of Kerala

Period of Study: 16/02/2022 to 15/02/2024

Project Coordinator: Prof. Valsamma Joseph

PI: Dr. Sajeevan T. P., Dr.Jayesh Puthumana

Co-I: Mr. Shibin S. P. (Co-Investigator) 

Project Cost: Rs. 372.43 lakhs

Integrated genomic and metabolomic approach for the discovery of novel small molecules with anticancer activity from marine microorganisms R

Funding Agency: DBT, Govt.of India

Period of Study: 28/10/2021- 27/10/2024

PI: Dr. Sajeevan T. P.

Project Cost: Rs. 83.0416 lakhs

Microbiome of Glaciomarine system of Svalbard; diversity and its variability.

Funding Agency: Ministry of Earth Sciences

Period of Study: 05/07/2019 – 04/07/2022

Co-PI: Dr. Sajeevan T. P.

Project Cost: Rs. 40.843 lakhs

Establishment of Bioinformatics and Computational Biology Centre for Marine Bio-resource Conservation and Sustainable Utilization

Funding Agency: Department of Biotechnology, Govt. of India

Period of Study: 22/02/21-21/02/26

PI: Prof. Valsamma Joseph,  Dr.Sajeevan T. P., Prof.I.S. Bright Singh, Dr.Jayesh Puthumana, Mr. Shibin S. P.

Project Cost: Rs. 74.99 lakhs

Development of bioprocess for the production of a high-quality protein hydrolysate, edible calcium, and medical-grade collagen from NCAAH- RAS Fish post filleting.

Funding Agency: Seed Money Research Initiative- Cochin University of Science and Technology.

Period of Study: 22/07/2022 to 21/07/2024

PI: Mr. Shibin S. P.

Project Cost: Rs. 1.0 lakhs

 

Bioprospecting of Marine microbial diversity for various products under the Marine Bioresource and Biotechnology Network Programme

Funding Agency: Department of Biotechnology, Govt of India

Project Type: Single Institutional

Period of Study: 28/09/2021 to 27/09/2024

PI: Dr. Sajeevan T. P.

Project Cost: Rs. 83.0416 lakhs

 

 

Completed Projects

Bioprospecting for Neuroprotective compounds from an endosymbiotic fungi Aspergillus MCCF102 isolated form a marine sponge as potential drug candidates against neurodegenerative disorders

Funding Agency: Department of Biotechnology, Govt.of India

Period of Study: 22/02/2019- 21/02/2022

PI: Dr. Sajeevan TP

Project Cost: Rs. 53.886 lakhs

Bioprospecting for antitumor molecules from marine actinomycetes M

Funding Agency: University Grants Commission

Period of Study: 07-06-2012  – 06-06-2014

PI: Sajeevan TP

Project Cost: 3.83   lakhs

Bioactive peptides and Depsipeptides with potential anticancer activity from marine sponges and tunicates of Indian Ocean M

Funding Agency: Kerala State Council for Science, Technology and Environment
Period of Study:
16-09-2015 – 15-09-2018
PI: Sajeevan TP
Project Cost: 24.45 lakhs

Molecular screening, cell culture based isolation and characterization of finfish and shellfish viruses and establishment of National Repository

Funding Agency: Department of Biotechnology, Govt.of India

Project type: Multi-Institutional project

Period of study: 09/7/2017- 31/03/2021

Project Coordinator: Prof. I. S. Bright Singh

Principal Investigator: Dr. Sajeevan TP

Project Cost: 118.66 lakhs

Collaborators: 

  1. C. Abdul Hakeem College, Melvisharam, Vellore Dist., Tamil Nadu.
    Principal Investigator: Dr. A. S. Sahul Hameed
  2. Central Institute of Freshwater Aquaculture, Bhubaneswar, Odisha.
    Principal Investigator: Dr. Pramoda Kumar Sahoo
  3. Central Institute of Fisheries Education, Mumbai, Maharashtra.
    Principal Investigator: Dr. Rajendran K.V.
  4. Sher – E- Kashmir University of Agricultural Sciences Technology, Kashmir, Jammu & Kashmir
    Principal Investigator: Dr. Feroz A. Shah
Isolation and chemical characterisation of anticancer metabolites from marine actinomycetes and elucidation of mechanisms anticancer activity through Functional Signature Ontology (FUSION) mapping

Funding Agency: UGC, under Raman Fellowship for Post Doctoral Research in USA

Period of Study: 09-11-2016 – 31-09-2017

PI: Dr. Sajeevan TP  

Project Cost: USD 37200/+ Rs 50,000/-

Nutritional evaluation, segregation and production optimization of novel marine microalgae for establishment as live feeds in fish and shellfish culture

Funding Agency: DBT, Govt. of India

Period of Study: 20/6/2018-19/6/2021

Co-PI: Dr. Sajeevan TP

Project Cost: 70.912 lakhs

Marine synthetic biology: building national capacity and human resources

Funding Agency: Department of Biotechnology, Govt. of India

Period of Study: 28/12/2017 -27/12/2020

Co-PI: Dr. Sajeevan TP

Project Cost: 51.49 lakhs

Indo-US initiatives on innovative reforms in marine biotechnology education and research and development of sustainable aquaculture production systems for inclusive economic growth and sustainable development

Funding Agency: University Grants Commission, Govt. of India (under the Indo-US 21st Century Knowledge Initiative)
Period of Study: 01.08.2015-31-07-2018
Co-PI: Sajeevan TP
Project Cost: 125.29 lakhs

Metabolite engineering in Penaeus monodon to accomplish maturation and spawning under captivity by way of RNA mediated silencing of CMG family hormones genes

Funding Agency:  UGC – BSR faculty Fellowship, University Grants Commission, New Delhi;
Period of Study: 2nd May 2015 to 1st May 2018
Project Cost: Rs. 25.74.

Selection and identification of immunocompetent early life stages of the giant fresh water prawn Macrobrachium rosenbergii based on differential mRNA expression.

Period of Study: 19-6-2013 to 18-6-2016
Funding Agency:Department of Science and Technology, Government of India
Project Cost:Rs. 43.67 lakhs

Detailed performance evaluation and accelerated commercialization of the nitrifying bioreactor technology in Indian market – Phase II.

Funding Agency: Department of Biotechnology, Government of India, Under SBIRI Scheme
Period of Study: 7-11-2013 to 7-11- 2016
Project Cost: Rs. 15.0 lakhs

Polyhydroxy butyrate from marine microorganisms for biomedical and aquaculture applications.

Funding Agency: Centre for Marine Living Resources and Ecology, Ministry of Earth Science, Government of India
Period of Study: 1-4-2012 to 31-3-2017
Project Cost: Rs.87.0 Lakhs.

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Development and optimization of vaccine to protect shrimp from white spot syndrome virus

Funding Agency: Department of Biotechnology, Government of India,
Period of Study: 24 -8-2009 to 31-3-2014
Project Cost: Rs. 57.03 Lakhs

Metagenomic approach to cloning and expression of endo and exo glucanase and β- 1,4 glucosidase from soil water system

Funding Agency: Department of Biotechnology, Government of India,
Period of Study: 28-9-2010 to 27-9-2014
Project Cost: Rs. 40.02 lakhs.

Optimization of the bioremediation technology developed for shrimp culture under closed system mode

Funding Agency: Ministry of Earth Science, Government of India,
Period of Study: October 2008 to October2011
Project Cost: Rs. 23.832 lakhs 

Development of anti-WSSV drugs from mangrove plants endemic to Indian coastal zone

Funding Agency: Department of Biotechnology, Government of India,
Period of Study: October 2006 –September 2009
Project Cost: Rs. 37.45 Lakhs.

Expression of virulence of Vibrio harveyi in Organic Recirculation Prawn Seed Production System (ORPSPS) and its management

Funding Agency: UGC,
Period of Study: July 2007-June 2010
Project Cost: Rs. 9.276 Lakhs.

Design modification and commercialization of nitrifying bioreactor technology for the establishment of organic recirculation prawn seed production system (Phase- I)

Funding Agency: Department of Biotechnology, Government of India,
Period of Study: September 2007-August 2010
Project Cost: Rs. 10.37 lakhs. 

Identification and removal of blocks on in vitro transformation and establishment of cell lines from Penaeus monodon

Funding Agency: Department of Biotechnology, Government of India,
Period of Study: October 2007- September 2010
Project Cost: Rs. 31.76 lakhs. 

Development and amplification of CMG family recombinant hormones, their antagonists and RNAi technique for induced maturation and spawning of Penaeus monodon

Funding Agency: Department of Biotechnology, Government of India,
Period of Study: 28-3-2005 to 31-12-2008
Project Cost: Rs. 38.69 lakhs. 

Programme support in marine biotechnology.

Funding Agency: Department of Biotechnology, Government of India,
Period of Study: April 2005- September 2008
Project Cost: Rs.139 lakhs.

Nitrifying bioreactors integrated into prawn hatchery systems: Biofilm structure, population dynamics, and kinetic modeling.

Funding Agency: Department of Science and Technology (DST), Govt. of India.
Period of Study: August 2006- March 2009
Project Cost: Rs. 13.9 lakhs.

Diseases of ornamental fishes: aetiology, disease management and development of biosecurity packages for exotic species.

Funding Agency: The Marine Products Export Development Authority (MPEDA), Ministry of Commerce, Government of India.
Period of Study: May 2007
Project Cost: Rs 8.59625 lakhs.

Development of an appropriate technology for bioremediation in shrimp grow out systems for disease management, productivity and aquaculture environment protection

Funding Agency: Indian Council of Agricultural Research (ICAR), New Delhi
Period of Study: 2003 October – 2006 October
Project Cost: Rs. 15,87,616.0.

Development of a comprehensive microbial technology for the protection of the larvae of Macrobrachium rosenbergii from vibriosis in hatchery. M

Funding Agency: Department of Science and Technology (DST), Govt. of India
Period of Study: November 2001 to November 2004
Project Cost: Rs. 15, 06, 651.00.

Development of cell culture systems from penaeid prawns for the isolation of White Spot Virus. M

Funding Agency: Department of Biotechnology, Govt. of India.
Period of Study: November 1999 to March 2003
Project Cost: Rs. 19, 94, 000.00.

Demonstration and validation of the nitrifying bioreactors developed for penaeid and non penaeid closed hatchery systems. M

Funding Agency: Department of Biotechnology, Govt. of India
Period of Study: July 2001 to March 2003
Project Cost: Rs. 3,93,400.00

Systemic Ectodermal Mesodermal Baculovirus Disease in Penaeids – Epizootiology, Immunodiagnostics and vaccine. M

Funding Agency: Indian Council of Agricultural Research
Period of Study: April 1998 to April 2002
Project Cost: Rs. 11, 75,576.00.

Screening of commercially available aquaculture medicine for the management of luminescent vibrios in penaeid hatchery systems M

Funding Agency: Marine Products Export Development Authority of India
Period of Study: June 2001 to Nov 2001
Project Cost: Rs. 2, 21, 951.0

Development of Disease Diagnosis and Management Strategies in Finfish and Shellfish Culture Systems.

Funding Agency: Department of Fisheries, Govt. of Kerala
Period of Study: August 1998 to July 2001
Project Cost: Rs.10,00,000.00.

Development of primary cell cultures and cell lines from fresh water fishes to isolate viruses associated with EUS.

Funding Agency: State Committee on Science, Technology & Environment, Govt. of Kerala
Period of Study: January 1993 to January 1998
Project Cost: Rs. 2,17,150.00.

Development of bioreactors for nitrifying water in closed system prawn hatcheries.

Funding Agency: Department of Biotechnology, Govt. of India.
Period of Study: April 1995 to April 1998
Project Cost: Rs. 19,31,944.00

Coir Retting – Process upgradation and pollution abatement through Environmental Biotechnology.

Funding Agency: Coir Board
Period of Study: August 1993 to April 1998
Project Cost: Rs.5,99,200.0

Vibrionaceae associated with the larvae of Macrobrachium rosenbergii in hatchery – Systematics and pathogenicity.

Funding Agency: International Foundation for Science, Sweden
Period of Study: February 1990 to February 1995
Project Cost: US $ 9,600.00.

Vibrionaceae associated with the larvae of Penaeus indicus: Systematics and Pathogenicity.

Funding Agency: State Committee on Science, Technology & Environment. Govt. of Kerala. (Part of the Young Scientist award)
Period of Study: August 1990 to July 1992
Project Cost: Rs. 20,000.00.

Microorganisms associated with the eggs and larvae of Macrobrachium rosenbergii.

Funding Agency: Department of Science and Technology, Govt. of India, under the Young Scientist programme
Period of Study: January 1987 to July 1989
Project Cost: Rs. 98,000.0

Molecular screening, cell culture based isolation and characterization of finfish and shellfish viruses and establishment of National Repository

Funding Agency: Department of Biotechnology, Govt.of India

Project type: Multi-Institutional project

Period of study: 09/7/2017- 31/03/2021

Project Coordinator: Prof. I. S. Bright Singh

Principal Investigator: Dr. Sajeevan TP

Project Cost: 118.66 lakhs

Collaborators: 

  1. C. Abdul Hakeem College, Melvisharam, Vellore Dist., Tamil Nadu.
    Principal Investigator: Dr. A. S. Sahul Hameed
  2. Central Institute of Freshwater Aquaculture, Bhubaneswar, Odisha.
    Principal Investigator: Dr. Pramoda Kumar Sahoo
  3. Central Institute of Fisheries Education, Mumbai, Maharashtra.
    Principal Investigator: Dr. Rajendran K.V.
  4. Sher – E- Kashmir University of Agricultural Sciences Technology, Kashmir, Jammu & Kashmir
    Principal Investigator: Dr. Feroz A. Shah
Marine synthetic biology: building national capacity and human resource.

Funding Agency: Department of Biotechnology, Government of India,
Project type: Multi-Institutional
Period of Study:28-2-2017 to 27-2-2020
Project Cost: Rs. 51.49884.

Development and application of CMG family recombinant hormones, their antagonists and RNAi technique for induced maturation and spawning of Penaeus monodon.

Collaborators:  Central Institute of Brackishwater Aquaculture, Chennai
                                    Department of Zoology, Calicut University, Calicut.

Funding Agency: Department of Biotechnology, Govt. of India.

Period of Study: October 2005- September 2008,

Project Cost: Rs. 66.03 lakhs.

Development of appropriate bioremediation technology for zero-exchange creek-fed shrimp culture system.

Collaborator: M/s Pancham Aquaculture Limited, Mumbai.
Funding Agency: Department of Biotechnology, Govt. of India under the Institute-Industry Collaboration Programme.
Period of Study: September 2004 – September 2007
Project Cost: Rs. 19,38,000.00.

Detection, isolation and identification of anti-white spot syndrome virus molecules from selected species of marine biota and development of an anti-WSSV formulation.

Collaborator: National Centre for Cell Sciences, Pune.

Funding Agency: Department of Biotechnology, New Delhi.

Period of Study: 2003 September – 2005 September

Project Cost: Rs. 11, 65, 000.00.

Development and evaluation of small-scale solar treatment systems for contaminated drinking water.

Collaborator: University of Northumbria at Newcastle, U.K.
Funding Agency: The Wellcome Trust, UK.
Period of Study: November 2001 to June 2005,
Project Cost: UK Pounds 53,380.00.

Digitized inventory of marine bioresources with special reference to bacteria associated with marine plants and animals.

Collaborators: Multi-Institutional Consortium consisting of National Institute of Oceanography, Goa, Andhra University, Visakhapatnam, Annamalai University, Porto Novo and Cochin University of Science and Technology, Kochi.
Funding Agency: Department of Biotechnology and Department of Ocean Development, Govt. of India.
Period of Study: November 2001 to March 2003
Project Cost: Rs. 10,87,000.00.