- Karthika, R., George, I., Murugadas, V., Jeswin, J.,Sherin, P.S.A., Sanjeev, D., Visnuvinayagam, S., Manikanta, B., Prasad, M.M., Rao, B.M., 2021. Characterization of tailed phages against E. coli using DNA restriction digestion analysis. Fishery Technology 58, 53-58 view
- Jeong, J.M., Jeswin, J.,Bae, J.S.,Park, C.I., 2018. Differential expression of olive flounder (Paralichthysolivaceus) transcriptome during viral hemorrhagic septicemia virus (VHSV) infection at warmer and colder temperature. Data in Brief 19, 2023-2028 view
- Jeswin, J., Joo, M.S., Jeong, J.M., Bae, J.S., Choi, K.M., Cho, D.H., Park, S.I., Park, C.I., 2018. The first report of siglec-3/CD33 gene in a teleost (rock bream, Oplegnathusfasciatus): An analysis of its spatial expression during stimulation to red seabream iridovirus (RSIV) and two bacterial pathogens. Developmental and Comparative Immunology 84, 117-122 view
- Hwang, J.Y., Jeong, J.M., Kwon, M.G., Seo, J.S., Hwang, S.D., Son, M.H., Bae, J.S., Choi, K.M., Cho, D.H., Jeswin, J., Park, C.I., 2018. Olive flounder CD276 (B7-H3) a coinhibitory molecule for T cells: Responses during viral hemorrhagic septicemia virus (VHSV) stimulation. Fish and Shellfish Immunology73, 228-233 view
- Jeswin, J., Jeong, S.M., Jeong, J.M., Bae, J.S., Kim, M.C., Park, C.I., 2017. Molecular characterization of a T cell costimulatory receptor, CD28 of rock bream (Oplegnathus fasciatus): Transcriptional expression during bacterial and viral stimulation. Fish and Shellfish Immunology 66, 354-359 view
- Jeswin, J., Jeong, J.M., Shim, J.D., Bae, J.S., Park, C.I., 2017. Protective responses of two paralogs of granulocyte colony stimulating factor (GCSF) in rock bream, Oplegnathus fasciatus during bacterial and viral infection. Fish and Shellfish Immunology 65, 206-212 view
- Chen, R.Y., Shen, K.L., Chen, Z., Fan, W.W., Xie, X.L.,Meng, C., Chang, X.J., Zheng, L.B., Jeswin, J., Wang, K.J., Liu, H.P., 2016. White spot syndrome virus entry is dependent on multiple endocytic routes, recruits autophagy, and is strongly facilitated by the autophagy-related protein Cq-GABARAP in a CME-dependent manner. Scientific Reports 6, 28694 view
- Jeswin, J., Xie, X.L., Wang, K.J., Liu, H.P., 2016. Proteomic analysis by iTRAQ in hematopoietic stem cells from red claw crayfish Cherax quadricarinatus post infection of white spot syndrome virus. Fish and Shellfish Immunology 50, 288-296 view
- Anju, A.,Jeswin,J.,Thomas, P.C.,Vijayan, K.K., 2015.Messenger RNA expression of pattern recognition receptor proteins (PRP) in the pearl oyster Pinctada fucata in response to LPS stimulation. Indian Journal of Fisheries 62, 151-156 view
- Zheng, C.Q., Jeswin, J., Shen, K.L.,Lablche, M., Wang, K.J., Liu H.P., 2015. Detrimental effect of CO2-driven seawater acidification on a crustacean brine shrimp, Artemia sinica.Fish and Shellfish Immunology 43, 181-190 view
- Jeswin,J., Anju, A.,Thomas, P.C., Paulton, M.P., Vijayan, K.K., 2015. Analysis of viral load between different tissues and rate of progression of white spot syndrome virus (WSSV) in Penaeus monodon. Aquaculture Research 46, 2003-2012 view
- Anju, A.,Jeswin,J.,Thomas, P.C.,Vijayan, K.K., 2013. Molecular cloning, characterization and expression analysis of F-type lectin from pearl oyster Pinctada fucata. Fish and Shellfish Immunology35, 170-179 view
- Jeswin,J., Anju, A.,Thomas, P.C., Paulton, M.P., Vijayan, K.K., 2013. Survivability of Penaeus monodon during white spot syndrome virus infection and its correlation with immune related genes. Aquaculture 380-383, 84-90 view
- Jeswin,J., Anju, A.,Thomas, P.C., Paulton, M.P., Vijayan, K.K., 2013. Differential and additional expression of proteins in the subcellular organelles of Penaeus monodon (Fabricus) in response to white spot syndrome virus (WSSV) infection. Indian Journal of Fisheries 60, 99-106 view
- Anju, A.,Jeswin,J.,Thomas, P.C., Paulton, M.P., Vijayan, K.K.,2013. Molecular cloning, characterization and expression analysis of cytoplasmic Cu/Zn-Superoxide Dismutase (SOD) from pearl oyster Pinctada fucata. Fish and Shellfish Immunology 34, 946-950 view
Dr. Jeswin Joseph
Chief Minister’s Nava Kerala Post Doctoral Fellow
RNAi of STAT gene to protect the shrimp from WSSV infection
In shrimp aquaculture, the main pathogen is white spot syndrome virus (WSSV), which cause collapse of the culture within 3-10 days post infection. As part of controlling this virus, WSSV entry pathway inside the host can be targeted. Signal transducers and activators of transcription (STATs) are a family of latent cytoplasmic transcription factors that comprise seven members in mammals. Upon activation by tyrosine phosphorylation, STATs can dimerize and translocate into the nucleus where they bind to their cognate DNA response elements and trigger gene transcription. In mammals, STATs are usually the common target of viruses. Previous studies have shown that WSSV can induce shrimp STAT activation to facilitate the transcription of the viral gene ie1, suggesting that the activated STAT was conducive to WSSV infection. In our study we are focusing on utilizing RNAi of STAT gene to inhibit the replication of WSSV.
Publications
- Dong-He Cho, Jeswin Joseph, Ji-Min Jung, Gwang-Min Choi, Min-Soo Joo, Chan-II Park (2017). Characteristics and expression of T-cell surface antigen CD2 gene from rock bream (Oplegnathusfasciatus) and applicability as a marker. International symposium on Marine and agricultural genomics, Seoul, South Korea. April 19- 21, 2017. (Poster)
- Jin-Sol Bae, Jeswin Joseph, Gwang-Min Choi, Dong-Hee Cho, Min-Soo Joo and Chan-II Park (2017). Functional characterization of two novel piscidins from rock bream (Oplegnathusfasciatus). International symposium on fisheries science for future generations, Tokyo, Japan. September 22 -24, 2017. (Poster)
- Jeswin Joseph, M.P Paulton, P.C Thomas and K.K Vijayan (2011). Differential expression of immune related genes of tiger shrimp Penaeus monodon following experimental infection with analysis of White Spot Syndrome Virus (WSSV). Asia Pacific Aquaculture Conference organized by World Aquaculture Society and College of Fisheries, Kerala Agricultural University, India. January 17-21, 2011. (Oral)
- Jeswin Joseph, M.P Paulton, P.C Thomas and K.K Vijayan (2011). Quantitative analysis of White Spot Syndrome Virus (WSSV) progression in experimentally infected tiger shrimp Penaeus monodon. Asia Pacific Aquaculture Conference organized by World Aquaculture Society and College of Fisheries, Kerala Agricultural University, India. January 17-21, 2011. (Poster)
- Anju Antony,P.C Thomas, M.P Paulton, K.K Vijayan and Jeswin Joseph (2011). Expression analysis of genes involved in the biomineralization of Mebe pearl. Asia Pacific Aquaculture Conference organized by World Aquaculture Society and College of Fisheries, Kerala Agricultural University, India. January 17-21, 2011. (Poster)
- Jeswin Joseph, M.P Paulton and P.C Thomas(2011).WSSV induced host protein expressional variations in tiger shrimp Penaeus monodon.Indian Fisheries Forum organized by Central Marine Fisheries Research Institute, India. December 19-23, 2011. (Poster)
Mentor
Prof. I. S. Bright Singh 
Dr. Prem Kumar, a Senior Scientist in the Finfish Culture Division at the ICAR-Central Institute of Fisheries Education (ICAR-CIFE), is recognized for his contributions to finfish aquaculture and sustainable fish farming practices. His research focuses on advancing breeding, seed production, and grow-out techniques for economically important finfish species, essential for enhancing fish farming efficiency and profitability. Dr. Kumar has been instrumental in developing improved methods for breeding and rearing native fish species, supporting biodiversity conservation while boosting aquaculture productivity in India.
Dr. David Verner-Jeffreys is a Senior Scientist at WorldFish and an esteemed expert in aquatic animal health and aquaculture biosecurity. With a background in fish pathology and disease management, Dr. Verner-Jeffreys has dedicated his career to developing solutions that enhance disease prevention and sustainable health practices in aquaculture systems globally. His research focuses on combating infectious diseases that impact fish farming, particularly in developing countries, where aquaculture plays a crucial role in food security and livelihoods.
Dr. M. Shashi Shekhar, is a distinguished expert in aquatic animal health and environmental management in brackishwater aquaculture. With extensive experience in fish and shrimp health management, his work addresses critical challenges in disease prevention, environmental sustainability, and biosecurity, contributing to the growth and resilience of India’s brackishwater aquaculture sector. By emphasizing biosecurity, environmental monitoring, and eco-friendly health management practices, Dr. Shekhar has contributed to enhancing the resilience and sustainability of shrimp and fish farming.
Dr. K.V. Rajendran is a prominent aquaculture scientist at the ICAR-Central Institute of Fisheries Education (ICAR-CIFE) in India, recognized for his expertise in fish health management and aquatic animal disease control. With a focus on advancing disease diagnostics, biosecurity, and sustainable health practices in aquaculture, Dr. Rajendran’s work has greatly contributed to improving the resilience and productivity of India’s aquaculture sector. His research addresses major challenges related to fish and shellfish health, particularly in diagnosing and managing viral, bacterial, and parasitic diseases that impact farmed species.
Dr. T. Raja Swaminathan is a renowned scientist at the ICAR-Central Institute of Fisheries Technology (ICAR-CIFT) in Kochi, India, with expertise in fish health management, aquaculture biosecurity, and disease diagnostics. His work focuses on addressing challenges related to aquatic animal health, particularly in ensuring sustainable and safe practices in India’s aquaculture industry. Dr. Swaminathan is recognized for his contributions to the detection and control of fish and shellfish diseases, which are critical for enhancing productivity and reducing economic losses in aquaculture.
Dr. Neeraj Sood, a distinguished scientist at the ICAR-National Bureau of Fish Genetic Resources (ICAR-NBFGR) in India, is recognized for his work in fish genetics, conservation, and sustainable aquaculture practices. His research focuses on the genetic characterization and conservation of fish biodiversity, which is critical for protecting valuable genetic resources and promoting sustainable aquaculture. By identifying and cataloging fish species and their genetic diversity, Dr. Sood has contributed to the preservation of native fish species, ensuring that these resources can support resilient and productive aquaculture systems in India.
Dr. B. Santhosh, a leading scientist at the Vizhinjam Regional Centre of the ICAR-Central Marine Fisheries Research Institute (ICAR-CMFRI), is known for his impactful contributions to marine aquaculture and coastal fisheries development in India. His work focuses on advancing sustainable practices in mariculture, particularly in seed production, hatchery technology, and the cultivation of high-value marine species like finfish, shellfish, and sea cucumbers. Dr. Santhosh’s research has played a critical role in supporting livelihood opportunities for coastal communities by promoting aquaculture as a viable and environmentally sustainable industry.
Dr. Victoria Alday-Sanz is a renowned aquaculture expert at National Aquaculture Group (NAQUA) in Saudi Arabia, recognized globally for her work in shrimp health management, biosecurity, and sustainable aquaculture practices. With a background in veterinary science and extensive experience in aquatic animal health, Dr. Alday-Sanz has played a critical role in advancing shrimp farming practices to enhance productivity while maintaining rigorous biosecurity standards. Her work is instrumental in addressing major health challenges in shrimp aquaculture, particularly in the prevention and management of viral and bacterial diseases that can impact large-scale operations.
J.M.P.K. Jayasinghe is a distinguished figure in aquaculture, known for his contributions to sustainable fish farming practices, particularly in Asia. With a focus on innovative aquaculture technologies and resource management, he has dedicated his career to improving the productivity, efficiency, and environmental sustainability of aquaculture systems. Jayasinghe has been involved in developing best practices that help small-scale and commercial farmers enhance yields while minimizing the environmental impact, which is crucial for both economic growth and ecological health.
Dr. Vasant Kripa is the former Secretary of the Coastal Aquaculture Authority (CAA) in Chennai, India, and a highly respected scientist in marine biology, coastal aquaculture, and environmental management. With a career spanning over three decades, Dr. Kripa has been instrumental in developing policies and practices that promote sustainable and responsible coastal aquaculture in India. Her work has focused on balancing the growth of aquaculture with environmental conservation, ensuring that coastal ecosystems remain resilient and productive.
Dr. K.M. Shankar is the Vice Chairman of the Asian Fisheries Society, Indian Branch, and former Dean of the College of Fisheries in Mangalore, India. A highly respected figure in fish health management and aquaculture, Dr. Shankar has contributed significantly to advancing aquaculture science, particularly in aquatic animal health, biotechnology, and sustainable fisheries. His research focuses on pathogen detection, disease management, and biosecurity in aquaculture, addressing key challenges to improve productivity and sustainability in the industry.
Prof. Arun K. Dhar is a Professor and Director of the Aquaculture Pathology Laboratory at the School of Animal & Comparative Biomedical Sciences, The University of Arizona, USA. An expert in aquaculture pathology and virology, Prof. Dhar is highly regarded for his research on diseases affecting shrimp and other aquatic species. His work focuses on identifying, understanding, and managing viral pathogens that pose significant threats to aquaculture industries globally.
Dr. Iddya Karunasagar is a distinguished Indian microbiologist and food safety expert, known for his pioneering work in aquatic microbiology, aquaculture health, and public health. His research focuses on seafood safety and disease management in aquaculture, with significant contributions to understanding and controlling microbial pathogens, such as Vibrio species, which affect marine organisms. His work has helped develop diagnostic tools and strategies that promote sustainability in aquaculture and ensure safer seafood.
Dr. Pramoda Kumar Sahoo is the Director-cum-ICAR National Professor at the Indian Council of Agricultural Research-Central Institute of Freshwater Aquaculture (ICAR-CIFA). A leading expert in fish health management and aquatic animal diseases, Dr. Sahoo’s work focuses on advancing disease control, immunology, and molecular biology in freshwater aquaculture. His research is pivotal in improving the health, resilience, and sustainability of India’s aquaculture industry, which plays a vital role in food security and rural livelihoods.
Dr. Rohana Subasinghe is the Managing Director of FutureFish, a consultancy specializing in sustainable aquaculture and fisheries development. With over 30 years of experience in aquaculture, aquatic animal health, and international fisheries, Dr. Subasinghe is a globally recognized expert dedicated to promoting sustainable practices that support food security, environmental protection, and socioeconomic growth.
Dr. Eduardo Leano is the Director General of the Network of Aquaculture Centres in Asia-Pacific (NACA), an intergovernmental organization focused on sustainable aquaculture development in the Asia-Pacific region. With a strong background in aquatic animal health and pathology, Dr. Leano has dedicated his career to advancing sustainable aquaculture practices, improving disease management, and promoting biosecurity within the industry.