Dr. Manomi S

Post Doctoral Fellow

Development of Low-cost Multivalent Non-antibiotic IgY-based Oral Edible Vaccine (LoMNA-IOV) as Biotherapeutics to Combat Major Bacterial Diseases Affecting Aquaculture in Kerala

The proposed research aims at developing low cost multivalent IgY antibody based biotherapeutics (LoMNA-IOV) against bacterial fish diseases affecting aquaculture in Kerala. The Immunoglobulin Y (IgY) antibodies would be raised in chicken against the aetiologies of 6 bacterial diseases such as vibriosis, aeromoniasis, edwardsiellosis, mycobacteriosis, streptococcosis and flavobacteriosis. Compared with the IgG productivity more IgY can be obtained from chickens due to the continuous secretion of IgY in the body and accumulation in the eggs. For therapeutic/prohylaxix purpose, and to reduce the production cost, whole egg yolk powder will be used, instead the purified IgY antibodies. The edible form of IgY antibody can be delivered orally and the same can be administered as prophylaxis and preventive health care along with probiotics and feed supplements as surface coatings of feed.

Awards/ Honours/ Fellowships/ Scholarships

  1. Chief Minister’s Nava Kerala Post-Doctoral Fellowship (2022).
  2. UGC-NETin Environmental Sciencein 2019.
  3. DST sponsored INSPIRE JRF fellowship (2013 -2018).
  4. 1st rank in MSc Marine Biology, Cochin University of Science and Technology, 2011.
  5. 14th rankat State level for academic excellence in SSLC Examination,2003.

Mentor

Dr. Jayesh Puthumana

Publications

  1. Ajitha V, Sarasan M, Sreevidya C P, Aswathy C, Kachiprath B, Mohandas A, Singh I S B, Hameed A S S, Schlenk D, Magnuson J T, Puthumana J. 2021. Cytotoxic impacts of treated electroplating industrial effluent and the comparative effect of their metal components (Zn, Hg, and Zn+Hg) on Danio rerio gill (DrG) cell line. Sci. Total Environ. 793,148533.
  2. Ajitha V, Sreevidya C P, Sarasan M, Park J C, Mohandas A, Singh I S B, Puthumana J, Lee J S. 2021. Effects of zinc and mercury on ROS-mediated oxidativestress-induced physiological impairments and antioxidant responsesin the microalga Chlorella vulgaris. Environ. Sci. Pollut. Res. https://doi.org/10.1007/s11356-021-12950-6.
  3. Sarasan M, Job N, Puthumana J, Ravinesh R, Kachiprath B, Philip R. 2020. Enzyme profiling of macroalgal endophytes: An attempt to uncover the arsenal of novel biocatalysts. J. Mar. Biol. Ass. India, 62 (2):1-5.
  4. Sarasan M, Job N, Puthumana J, Ravinesh R, Prabhakaran M P, Thomas L C, Philip R. 2020.Exploration and profiling of hidden endophytic mycota of marine macroalgae with potential drug leads. FEMS Microbiol. Lett., 367:
  5. Olokkaran R, Mathew S, Philip R, Kachiprath B, Sarasan M. 2019. Molecular identification of aflatoxigenicAspergillus flavus isolated from finished feed for farmed Nile tilapia, Oreochromisniloticus (Linnaeus, 1758). Int. J. Fish. Aquat Res., 4(4): 20-25.
  6. Sarasan M, Puthumana J, Job N, Han J, Lee J S, Philip R. 2017.Marine algicolous endophytic fungi- A promising drug resource of the era. Microbiol. Biotechnol. 27(1): 1039-1052.
  7. Kachiprath B, Jayanath G, Solomon S,Sarasan M. 2017. CTAB influenced differential elution of metagenomic DNA from saltpan and marine sediments. 3 Biotech, 8:44.
  8. Ramees R M, Solomon S, Athira N R,Sarasan. 2017. Artisanal Fishing in Kerala Backwaters:A Socioeconomic Assessment of Indian Coracles. Asian J AgricultExtenEconmSociol, 21(3): 1-8.
  9. Princy K F, SarasanM, Philip R and Gopinath A. 2016. Antibacterial and catalytic efficacy of biosynthesized silver nanoparticles using marine seaweed Padinatetrastromatica. Nano Biomed. Eng. 8(1): 16-23.
  10. Sarasan M, Job N and Philip R. 2015. Bioactive potential of endophytic fungi from macroalgae. J. Res. Mar. Sci. 4(2): 27-32.
  11. Job N, Sarasan M and Philip R. 2015. Isolation and characterization of endophytic fungi from Avicenia officinalis. J. Res. Biomed. Biotech. 5(1): 4-8.
  1. Manomi S, Divya T Babu, BhavyaKachiprath, Neema Job, JayeshPuthumana, Swapna P Antony, Rosamma Philip.2022. Application of endophytic Penicilliumcitrinumextract to control Vibrio harveyi in Penaeus monodon culture system. Proceedings of the 34th Kerala Science Congress, pp.313-314.
  2. Manomi S, Neema Job, JayeshPuthumana, Ravinesh R,Rosamma Philip. 2020. Biocatalytic potential of algicolous endophytes with special reference to asparaginase activity. Book of abstracts of International Symposium Marine Ecosystems Challenges & Opportunities (MECOS 3), pp.467.
  3. Divya T. Babu”, Manomi S, Anju, M.V., DhanyaKesavan,Rosamma Philip. 2020. A Marine Actinomycete, Streptomyces fradiae A3 as an Antagonistic Agent to Vibrios in Penaeus monodon Rearing System. Book of abstracts of International Conference on Impact of Climate Change on Hydrological Cycle, Ecosystem, Fisheries and Food security (ClimFIshCon-2020), pp.99.
  4. Manomi S, Neema Job, JayeshPuthumana, Franklin John, Georgina Grace, Sajeevan T, IS Bright Singh, Rosamma Philip. 2019. Bioprospecting of an algicolous endophyte Aspergillus terreus for its antimicrobial potential. Book of abstracts of International Conference on Frontiers in Marine Science Challenges and Prospects (MARICON-2019), pp. 258.
  5. Neema Job, Manomi S, Rosamma Philip. 2019. Hidden fungi of milky mangrove, Excoecaiuaagallocha as a source of hydrolytic enzymes and antimicrobial compounds. Book of abstracts of International Conference on Frontiers in Marine Science Challenges and Prospects (MARICON-2019), pp.192.
  6. Revathy M R, Manomi S, Jisha Jose, Rosamma Philip. 2019. Antibacterial activity of the endophytic fungi from the mangrove plant, Aegicerascorniculatum. Proceedings of the 31st Kerala Science Congress, pp.189-190.
  7. Revathy M R, Manomi S, Jisha Jose, Rosamma Philip. 2019. Production of Antibacterial Compounds by Mangrove Associated Endophytic Fungi. Proceedings of National seminar on Aquatic Chemistry AQUASEM-19, pp.63.
  8. Manomi S, Neema Job, JayeshPuthumana, Ravinesh R, Prabhakaran M P, Farha A, Rosamma Philip. 2018. Algicolous endophytes: Diversity hotspots of mycobiota. 4th World Conference on Marine Biodiversity (WCMB 2018), Montreal’s Palais des congrès, Canada.
  9. Manomi S, Neema Job, JayeshPuthumana, Ravinesh R, Rosamma Philip. 2018. Cellulase production by algicolous endophytes utilizing water hyacinth. Proceedings of the International Conference on EMAEH, pp. 71-72.
  10. Anupama K, Manomi S, BhavyaKachiprath, Revathy M R, Induja D K, Neema Job, Rosamma Philip. 2018. Community structure and bioactive potential of endophytic fungi from the Indian mangrove, Avicennia officinalis. Proceedings of the International Biodiversity Congress, pp.38.
  11. Manomi S, Neema Job,Rosamma Philip. 2016. Endophytic fungi: A new wave of metabolites for future. Proceedings of the National Conference on Fungal Biotechnology-NCFB-16, pp.79.
  12. Neema Job, Manomi S,Rosamma Philip. 2016. Laccase production by an endophytic fungus Alternariatenuissima isolated from mangrove apple, Sonneratiacaseolaris. Proceedings of the National Conference on Fungal Biotechnology-NCFB-16, pp.129.
  13. Manomi S, Neema Job,Rosamma Philip. 2016. Bioactive potential of endophytic black yeast Horteawerneckii from Sargassum Proceedings of the 28th Kerala Science Congress, pp.1882-1883.
  14. Neema Job, Manomi S,Rosamma Philip. 2016. Endophytic Penicilliumcitrinum from Kandeliacandel as a source of enzymes and antimicrobial compounds. Proceedings of the 28th Kerala Science Congress, pp. 2060-2061.
  15. Manomi S, Neema Job,Rosamma Philip. 2015. Endophytic yeast from seaweeds: a rich source of functional metabolites. Proceedings of World Ocean Science Congress, pp. 73.
  16. Manomi S, Neema Job,Rosamma Philip. 2015. Endophytic Penicillium from seaweeds, Proceedings of the 27th Kerala Science Congress, pp.10-26.
  17. Neema Job, Manomi S,Rosamma Philip. 2015. Endophytic fungi from mangrove plant Avicenia marina. Proceedings of World Ocean Science Congress, pp. 19.
  18. Neema Job, Manomi S,Rosamma Philip. 2015. Isolation and characterization of endophytic fungi from Avicenia officinalis. Proceedings of the 27th Kerala Science Congress, pp. 10-10.
  19. Manomi S, Neema Job,Rosamma Philip. 2014. Seaweeds – An ecological niche for endophytic fungi. Abstracts of second Indian Biodiversity congress, pp100.
  1. Training Course on “Molecular Analysis of DNA & RNA by Semi-quantitative and Real time PCR methods” organized by SIBB-R&D, Cochin during 15-31 July 2019.
  2. Workshop on “Statistical tools for Marine Biologists” organized by Dept. of Marine Biology, Microbiology and Biochemistry, Cochin University of Science and Technology, Cochin during 27-31 March 2017.
  3. National workshop on “Emerging Trends in Chromatography and Hyphenated” at School of Marine Sciences, Cochin University of Science And Technology on 23rd September 2016.
  4. 4th National workshop on “Taxonomy, Biodiversity, Ex-situ Conservation and Applications of Fungi”organized by National Fungal Culture Collection of India (NFCCI), MACS’ Agarkar Research Institute, Pune, from 01-10 June 2016.
  5. Workshop on “Linux based analysis tools for researchers using open source software R” organized by Dept. of Marine Biology, Microbiology and Biochemistry, Cochin University of Science and Technology, Cochin during 2th February to 4th March 2016.
  6. Training programme on “Molecular Markers for Genetic Analysis” conducted by Peninsular and Marine Fish genetic Resources Centre, NBFGR, Cochin during 14-19 December 2015.
  7. Workshop on “Linux Productivity Tools for Researchers- Libre Office, Mendeley and Latex” organized by Dept. of Marine Biology, Microbiology and Biochemistry, Cochin University of Science and Technology, Cochin during 18-21 February 2015.
  8. National Workshop on “Ensuring Quality in Scientific Research” organized by School of Marine Sciences in association with Centre for Information Literacy Studies, University of Kerala and Kerala Library Association, Ernakualm during 7-8 January 2015.
  9. Workshop on “Data Processing and Presentation in Marine Sciences using Open Source Software Tools” organized by Dept. of Marine Biology, Microbiology and Biochemistry, Cochin University of Science and Technology, Cochin during 24-28 March 2014.
  10. National Workshop on “Concepts and practices in Ecology of Plant-Animal Interactions” organized by Dept. of Animal Science, Central University of Kerala during 20-17 May 2014.
  11. Workshop on “Sequence Analysis and Molecular Docking” organized by Dept. of Marine Biology, Microbiology and Biochemistry, Cochin University of Science and Technology, Cochin during 27 March 2013.

Genbank Submissions: 149