Soumya Balakrishnan

Research Scholar

Development of cell culture systems from marine molluscs

Bivalve aquaculture is of global significance contributing greatly to the economy. Pathogenic outbreaks leading to mass mortalities are also common. However, important tools such as bivalve cell lines to investigate pathogenic infections are still not available. In this context, our focus is on developing cell culture systems from bivalves (oysters) and attempting possible transfection/transduction (pre-requisites for inducing immortalization in cells) in the developed cell culture systems, besides other applications such as toxicity studies.

AWARDS

  1. Best Oral Presentation Award for the paper entitled “Cell cultures from the oyster, Magallana bilineata as a platform for toxicity evaluation and transgene expression” at the 3rd International Aquatic Biotechnology Symposium organized by Istanbul University Faculty of Aquatic Sciences, Istanbul, Türkiye from 25 to 27 September 2024.
  2. Second Prize in Oral Presentation for the paper entitled “Heart tissue of the Indian backwater oyster Crassostrea madrasensis as the best source of primary cells for the development of a cell culture system” in the National Seminar on Recent Trends in Aquaculture organized by the Department of Marine Biology, Microbiology and Biochemistry, School of Marine Sciences, Cochin University of Science and Technology, Kochi, Kerala, India during 09 and 10 March, 2023.

Publications

  • Balakrishnan S, Sajeevan AKM, Parvathi SC, Singh ISB, Puthumana J (2024). An optimized protocol for routine development of cell culture from adult oyster, Crassostrea madrasensis. Cell Biology International, 48, 923-938. https://doi.org/10.1002/cbin.12159
  • Balakrishnan, S., Singh, I.S.B., Puthumana, J., 2022. Status in molluscan cell line development in last one decade (2010–2020): impediments and way forward. Cytotechnology, 74, 433–457. https://doi.org/10.1007/s10616-022-00539-x  
  • Balakrishnan, S., Ameer, A., Pazhur Mohandas, S., Maliyekkal Sajeevan, A.K., Bhaskaran Sathyabhama, A., Singh, B., 2022. Pyocyanin as a safe aquaculture drug for the control of vibriosis in shrimp recirculating aquaculture system (RAS). Aquac. Int. 30, 2129–2144. https://doi.org/10.1007/s10499-022-00890-y

Supervising Guide

Prof. I. S. Bright Singh

Dr. Jayesh Puthumana